Imathiriyeli ye-IVD ye-reagent ye-Cardiac marker

I-Cardiac Troponin I (cTnI) i-subtype yentsapho ye-troponin esetyenziswa ngokuqhelekileyo njengophawu lomonakalo we-myocardial.I-Cardiac troponin I ikhethekileyo kwizicubu zenhliziyo kwaye ifunyenwe kwi-serum kuphela ukuba kwenzeke ukulimala kwe-myocardial.Ngenxa yokuba i-cardiac troponin I isalathiso esibucayi kunye nesicacileyo somonakalo we-heart muscle (myocardium), amanqanaba e-serum angasetyenziselwa ukunceda ukwahlula phakathi kwe-angina engazinzanga kunye ne-myocardial infarction (i-heart attack) kubantu abaneentlungu zesifuba okanye i-acute coronary syndrome.

I-isoform ye-cardiac ye-TnT isetyenziswa ngokubanzi njengophawu lokulimala kweseli ye-myocardial, njengokuba i-cTnI injalo.I-cTnT ine-kinetics yokukhululwa efanayo kwi-bloodstream kunye novakalelo olufanayo lokulimala okuncinci kwe-myocardial njenge-cTnI.Kwigazi lezigulane ze-acute myocardial infarction (AMI), i-cTnT isoloko ifumaneka kwifomu yasimahla ngelixa i-cTnI ifumaneka kakhulu kwi-complex ne-TnC.

I-Troponin C, eyaziwa ngokuba yi-TN-C okanye i-TnC, yiprotheyini ehlala kwi-troponin complex kwi-actin filaments encinci ye-striated muscle (intliziyo, i-skeletal ekhawulezayo, okanye i-skeletal-twitch-twitch skeletal) kwaye inoxanduva lokubopha i-calcium ukuze isebenze. ukufinyela kwemisipha.I-Troponin C ifakwe kwikhowudi ye-TNNC1 yofuzo ebantwini kuzo zombini i-cardiac kunye ne-skeletal muscle.

i-myoglobin yiprotheni ye-cytoplasmic ebopha i-oksijini kwiqela le-heme.Ineqela elinye kuphela leglobulin, ngoxa ihemoglobin inezine.Nangona iqela layo le-heme lifana nalawo akwi-Hb, i-Mb inobudlelwane obuphezulu be-oksijini kune-hemoglobin.Lo mahluko unxulumene nendima yawo eyahlukileyo: ngelixa i-hemoglobin ihambisa ioksijini, umsebenzi we-myoglobin kukugcina ioksijini.

I-Digoxin isetyenziselwa ukunyanga ukusilela kwentliziyo, ngokuqhelekileyo kunye namanye amayeza.Ikwasetyenziselwa ukuphatha iintlobo ezithile zentliziyo engaqhelekanga (ezifana ne-fibrillation ye-atrial engapheliyo).Ukunyanga ukusilela kwentliziyo kunokunceda ukugcina amandla akho okuhamba kunye nokuzilolonga kwaye kunokuphucula amandla entliziyo yakho.Ukunyanga ukubetha kwentliziyo okungaqhelekanga nako kunokuphucula isakhono sakho sokuzilolonga.I-Digoxin yeyodidi lwamayeza abizwa ngokuba yi-cardiac glycosides.Isebenza ngokuchaphazela iiminerali ezithile (i-sodium kunye ne-potassium) ngaphakathi kweeseli zentliziyo.Oku kunciphisa ukuxinezeleka kwentliziyo kwaye kuyincede igcine ukubetha kwentliziyo okuqhelekileyo, okuzinzileyo nokunamandla.

I-CK-MB kwi-acute myocardial infarction (AMI), kunye ne-CK-BB kumonakalo wengqondo kunye ne-tumor eyingozi ye-gastro-intestinal tract.I-CK-MB ilinganiswa nokuba ngumsebenzi we-enzyme okanye ugxininiso lobuninzi kwaye ilinganiswa njengommakishi kungekhona nje ekuxilongweni kwe-AMI kodwa nakwi-AMI ekrokrelwayo kunye ne-angina engazinzanga.

I-heart-type-Fatty-Acid-Binding-Protein (hFABP) yiprotheni, ebandakanyeka kwi-intracellular myocardial transport (Bruins Slot et al., 2010; Reiter et al., 2013).Emva kokuba i-myocardial necrosis i-hFABP ikhutshwe ngokukhawuleza kumjelo wegazi kwaye ngoko yaphandwa njenge-biomarker ye-AMI.Nangona kunjalo, ngenxa yobuntununtunu obuphantsi kunye neenkcukacha ezithile ze-hFABP azizange zibonakaliswe ziluncedo, xa kuthelekiswa nokusebenza kokuxilonga kwe-hs-Tn assays (Bruins Slot et al., 2010; Reiter et al., 2013).

I-Lipoprotein-Associated Phospholipase A2(Lp-PLA2)

ILipids ngamafutha egazini lakho.I-Lipoprotein yindibaniselwano yamafutha kunye neeproteni ezithwala amafutha egazini lakho.Ukuba une-Lp-PLA2 egazini lakho, unokuba ne-fatty deposits kwi-artery yakho esemngciphekweni wokugqabhuka kwaye ubangele isifo senhliziyo okanye isifo.

I-D-dimer (okanye i-D dimer) yimveliso ye-fibrin degradation (okanye i-FDP), iqhekeza elincinci leprotheyini ekhoyo egazini emva kokuba i-blood clot ichithwe yi-fibrinolysis.Ibizwe ngolo hlobo ngenxa yokuba inamaqhekeza amabini eprotheni yefibrin edityaniswe yi-cross-link.