Ngomhla we-9 kaNovemba 2021, ukwahluka kweintsholongwane ye-corona entshaB.1.1.529 yabhaqwa okokuqala ngqa kwisampulu yetyala laseMzantsi Afrika.Ngaphantsi kweeveki ezi-2, uhlobo oluguqukileyo luye lwaba lolona hlobo lubalaseleyo losulelo olutsha lwaseMzantsi Afrika, kwaye ukukhula kwalo ngokukhawuleza kuvuselele ingqalelo yehlabathi.Ngomhla wama-26 kaNovemba, olu hlobo lokuguquka luye lwachazwa yi-WHO njengesihlanu "i-variant of concern" (VOC), ebizwa ngokuba yi-Omicron (Omicron) eguquguqukayo.Okwangoku, uhlobo olwahlukileyo lwe-Omicrom lunwenwele ngokukhawuleza kumazwe ali-19 okanye imimandla kwihlabathi liphela, kwaye lunokubangela umjikelo omtsha wemingeni enzima kuthintelo nolawulo lobhubhane wehlabathi.
I-WHO ikwatsho ukuba i-Omicron inenani elikhulu leenguqu, ezinye zazo ezixhalabisayo.I-WHO ikwathe i-"Omicron" ye-mutant strain ibonwa ngokukhawuleza kunezinye iintlobo eziguqukileyo ezibangele uqhaqho losulelo kwixesha elidlulileyo, ebonisa ukuba olu hlobo lwamva nje lunokuba nenzuzo yokukhula.Ukuthintela ngokuthe ngqo ukusasazeka kwe-mutant strain ye-coronavirus entsha i-Omicron iye yaba yinto ekujoliswe kuyo entsha yothintelo lobhubhane wehlabathi.
Imephu yokuhanjiswa kwenguqu ye-Omicron(1）kunye neDelta(2）, iYunivesithi yaseStanford iCoronavirus kunye neDatha yoKuchasa iziyobisi
Ukongeza ekubeni neenguqu ezininzi kwiprotein ye-spike, i-Omicron mutant strain nayo ineendawo ezininzi zokuguqula i-N protein.Kuba eyona nto iphambili ekujoliswe kuyo ye-coronavirus entsha yokufumanisa i-antigen reagent yiprotheyini ye-N, ukuguqulwa kweprotein ye-N kunokuchaphazela i-antigen entsha ye-coronavirus.Ukuchaneka kwekhithi yovavanyo kunempembelelo.
| Itheyibhile 1. Ukuthelekiswa kwe-N protein evolution yeenguqu ezahlukeneyo
| |
| Umcwe wentsholongwane
| N protein evolution |
| UAlfa(B.1.1.7) | I-R203K;G204R;(>50%) I-S194L(5-50%) D3H;D63G;T205I;M234I(1-5%) |
| I-Beta(B.1.351) | T205I (>50%) P13S;T3621(5-50%) Q9H;Q28R;A35T;E38V;Q418H (1-5%) |
| I-Gamma(p.1) | P80R;S202C;R203K;G204R (>50%) I-A211S;D402Y;S4131 (1-5%) |
| I-Delta(B.1.617.2) | D63G;R203M;G215C;D377Y (>50%) Q9L(>5-50%) I-G18V;R385K (1-5%)
|
| I-Omicron(B.1.1.529) | P13L;R203K;G204R E31/R32/S33 Del |
Xa kuthelekiswa neprotheni ye-Alpha-N, iprotheni ye-Omicron-N inomahluko we-10 izikhundla ze-amino acid.Ukuze kuphandwe ukusebenza kweprotein ye-Omicron-N yi-covid-19 ye-antibody ekrwada ye-Keygen gene, silungiselele iprotein ye-Omicron-N okokuqala ngqa, Kwaye senza ukuqinisekiswa okuhlangeneyo nguKeygen Gene kunye nenani labathengi.Iziphumo zibonisa ukuba umbono ovulekileyo wejini entsha yesithsaba isithsaba se-antibody sineziphumo ezifanayo zokufumanisa iprotheni ye-Omicron-N, iprotheni ye-Alpha-N kunye neprotheni ye-Delta-N.Imbonakalo evulekileyo yemfuza yesithsaba esitsha somthi we-antibody inokuqinisekisa ukuchaneka kwekhithi ye-antigen yentsholongwane yesithsaba ukuze kuchongwe ukwahluka kwe-Omicron..
| Itheyibhile 2 Iziphumo zokufunyanwa kwe-Omicron recombinant N protein nge-neocorona antibody | ||||||
| I-antibody Ngamabini | I-Alpha-Nprotein | I-Omicron-Nprotein | ||||
| 4.0ng/ml | 2.0ng/ml | 1.0ng/ml | 4.0ng/ml | 2.0ng/ml | 1.0ng/ml | |
| Isicwangciso soku-1 | G5 | G4 | G2 | G5 | G4 | G2 |
| Isicwangciso sesi-2 | G5 | G4 | G2 | G5 | G4 | G2 |
Ikhadi lokuchasa igolide yeColloidal
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Ixesha lokuposa: Dec-14-2021
