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Ukufunyaniswa kweprotein ye-N ephinda iphinda isebenze yohlobo lwe-Omicron eyahlukileyo yi-Covid-19 ye-monoclonal antibody ayichaphazeleki.

 

Ngomhla we-9 kaNovemba 2021, ukwahluka kweintsholongwane ye-corona entshaB.1.1.529 yabhaqwa okokuqala ngqa kwisampulu yetyala laseMzantsi Afrika.Ngaphantsi kweeveki ezi-2, uhlobo oluguqukileyo luye lwaba lolona hlobo lubalaseleyo losulelo olutsha lwaseMzantsi Afrika, kwaye ukukhula kwalo ngokukhawuleza kuvuselele ingqalelo yehlabathi.Ngomhla wama-26 kaNovemba, olu hlobo lokuguquka luye lwachazwa yi-WHO njengesihlanu "i-variant of concern" (VOC), ebizwa ngokuba yi-Omicron (Omicron) eguquguqukayo.Okwangoku, uhlobo olwahlukileyo lwe-Omicrom lunwenwele ngokukhawuleza kumazwe ali-19 okanye imimandla kwihlabathi liphela, kwaye lunokubangela umjikelo omtsha wemingeni enzima kuthintelo nolawulo lobhubhane wehlabathi.

 

I-WHO ikwatsho ukuba i-Omicron inenani elikhulu leenguqu, ezinye zazo ezixhalabisayo.I-WHO ikwathe i-"Omicron" ye-mutant strain ibonwa ngokukhawuleza kunezinye iintlobo eziguqukileyo ezibangele uqhaqho losulelo kwixesha elidlulileyo, ebonisa ukuba olu hlobo lwamva nje lunokuba nenzuzo yokukhula.Ukuthintela ngokuthe ngqo ukusasazeka kwe-mutant strain ye-coronavirus entsha i-Omicron iye yaba yinto ekujoliswe kuyo entsha yothintelo lobhubhane wehlabathi.

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Imephu yokuhanjiswa kwenguqu ye-Omicron(1kunye neDelta(2, iYunivesithi yaseStanford iCoronavirus kunye neDatha yoKuchasa iziyobisi

 

 

Ukongeza ekubeni neenguqu ezininzi kwiprotein ye-spike, i-Omicron mutant strain nayo ineendawo ezininzi zokuguqula i-N protein.Kuba eyona nto iphambili ekujoliswe kuyo ye-coronavirus entsha yokufumanisa i-antigen reagent yiprotheyini ye-N, ukuguqulwa kweprotein ye-N kunokuchaphazela i-antigen entsha ye-coronavirus.Ukuchaneka kwekhithi yovavanyo kunempembelelo.

 

 

Itheyibhile 1. Ukuthelekiswa kwe-N protein evolution yeenguqu ezahlukeneyo

 

Umcwe wentsholongwane

 

N protein evolution
UAlfa(B.1.1.7) I-R203K;G204R;(>50%)

I-S194L(5-50%)

D3H;D63G;T205I;M234I(1-5%)

I-Beta(B.1.351) T205I (>50%)

P13S;T3621(5-50%)

Q9H;Q28R;A35T;E38V;Q418H (1-5%)

I-Gamma(p.1) P80R;S202C;R203K;G204R (>50%)

I-A211S;D402Y;S4131 (1-5%)

I-Delta(B.1.617.2) D63G;R203M;G215C;D377Y (>50%)

Q9L(>5-50%)

I-G18V;R385K (1-5%)

 

I-Omicron(B.1.1.529) P13L;R203K;G204R

E31/R32/S33 Del

   

Xa kuthelekiswa neprotheni ye-Alpha-N, iprotheni ye-Omicron-N inomahluko we-10 izikhundla ze-amino acid.Ukuze kuphandwe ukusebenza kweprotein ye-Omicron-N yi-covid-19 ye-antibody ekrwada ye-Keygen gene, silungiselele iprotein ye-Omicron-N okokuqala ngqa, Kwaye senza ukuqinisekiswa okuhlangeneyo nguKeygen Gene kunye nenani labathengi.Iziphumo zibonisa ukuba umbono ovulekileyo wejini entsha yesithsaba isithsaba se-antibody sineziphumo ezifanayo zokufumanisa iprotheni ye-Omicron-N, iprotheni ye-Alpha-N kunye neprotheni ye-Delta-N.Imbonakalo evulekileyo yemfuza yesithsaba esitsha somthi we-antibody inokuqinisekisa ukuchaneka kwekhithi ye-antigen yentsholongwane yesithsaba ukuze kuchongwe ukwahluka kwe-Omicron..

 

Itheyibhile 2 Iziphumo zokufunyanwa kwe-Omicron recombinant N protein nge-neocorona antibody
I-antibody

Ngamabini

I-Alpha-Nprotein I-Omicron-Nprotein
4.0ng/ml 2.0ng/ml 1.0ng/ml 4.0ng/ml 2.0ng/ml 1.0ng/ml
Isicwangciso soku-1 G5 G4 G2 G5 G4 G2
Isicwangciso sesi-2 G5 G4 G2 G5 G4 G2

 

Imifanekiso ye3

                                                     Ikhadi lokuchasa igolide yeColloidal

 

Ngeisampulu nceda uqhagamshelane sales03@sc-sshy.com

 

 

 


Ixesha lokuposa: Dec-14-2021